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When Captain Jack Sparrow (Johnny Depp) crosses paths with a woman from his past (Penelope Cruz) he's not sure if it's love—or if she's a ruthless con artist who’s using him to find the Fountain of Youth. When she forces him aboard the ship of the formidable pirate Blackbeard (Ian McShane), Jack finds himself on an unexpected adventure in which he doesn’t know who to fear more: Blackbeard or the woman from his past.

Thrust into an all-new adventure, a down-on-his-luck Captain Jack Sparrow finds the winds of ill-fortune blowing even more strongly when deadly ghost pirates led by his old nemesis, the terrifying Captain Salazar (Bardem), escape from the Devil's Triangle, determined to kill every pirate at sea...including him. Captain Jack's only hope of survival lies in seeking out the legendary Trident of Poseidon, a powerful artifact that bestows upon its possessor total control over the seas.

This time around, Johnny returns as Captain Jack Sparrow and is caught in yet another tangled web of supernatural intrigue. It turns out, Captain Jack owes a blood debt to the legendary Davey Jones, ruler of the ocean depths and captain of the ghostly Flying Dutchman. If Jack can't figure a crafty way out of this one, he'll be cursed to an afterlife of eternal servitude and damnation. And as if that weren't enough, Captain Jack's problems throw a huge wrench into the wedding plans of the blissful Will Turner and Elizabeth Swann, who quickly find themselves thrust into Jack's misadventures.

Will Turner (Orlando Bloom), Elizabeth Swann (Keira Knightley) are allied with Captain Barbossa (Geoffrey Rush) in a desperate quest to free Captain Jack Sparrow (Johnny Depp) from his mind-bending trap in Davy Jones' locker, while the terrifying ghost ship, The Flying Dutchman and Davy Jones, under the control of the East India Trading Company, wreaks havoc across the Seven Seas. Navigating through treachery, betrayal and wild waters, they must forge their way to exotic Singapore and confront the cunning Chinese Pirate Sao Feng (Chow Yun-Fat). Now headed beyond the very ends of the earth, each must ultimately choose a side in a final, titanic battle, as not only their lives and fortunes, but the entire future of the freedom-loving Pirate way, hangs in the balance.

Described as a continuation of the Anne Hathaway-led series of films and not a reboot.