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Wayne Gretzky (Adam Johnson) is a vampire with teeth that won't grow. His impotence began when he inadvertently killed Mary, the love of his life, 300 years ago. To take his mind off the pain, he teaches college history—who better than a guy who's been around for centuries? Attempting to regain his full vampire powers, he enlists help from his friend and colleague, Dr. Levine (Gary Cole). Nothing works... that is until a new semester brings freshman Chris Keller (Julie Gonzalo)—a dead ringer for his beloved Mary. They begin to have an affair, which quickly goes south when he accidentally turns Chris into a vampire. Now, as she leaves a bloody trail of destruction across campus—converting a sorority house full of co-eds including the irresistible Samantha (Alexis Knapp) to her vampire legion—Wayne is faced with the task of stopping her before she kills half the student body!