Eligio (Gael Garcia Bernal), a fun-loving, charismatic actor wakes up one morning to realize that his wife Susana (Veronica Echegui) has left You're Killing Me Susanahim without a word or warning. Eligio discovers that she is in Iowa, so he sells off his car and gets on a plane from his native Mexico City to go after her.
From the moment he gets off the plane in the Midwest university town Eligio is like a fish out of water. Things only get worse when the short, dark and loquacious Eligio discovers Susana has started a relationship with huge, mysterious and pasty white poet Slawomir (Hlynur Harraldson).
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