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Driving home after a tense holiday weekend with his in-laws, Ray Monroe (Sam Worthington), a well-meaning but overwhelmed family man, pulls into a rest area with his wife Joanne (Lily Rabe) and daughter Peri (Lucy Capri). The trip takes a turn for the worse when Peri is hurt in an accident and the family rushes to a nearby emergency room run by a staff with dubious intentions. After being sent away for further testing Peri and Joanne vanish and all records of their visit disappear. Ray’s concern turns into a desperate race to find his family and discover the truth of what happened to them.
Follows a New York City cop (Sandler) as he finally takes his wife (Aniston) on a long-promised European trip. A chance meeting on the flight gets them invited to an intimate family gathering on the super-yacht of elderly billionaire Malcolm Quince. When Quince is murdered, the couple become the prime suspects in a modern-day whodunit.