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Hitman: Agent 47 centers on an elite assassin who was genetically engineered from conception to be the perfect killing machine, and is known only by the last two digits on the barcode tattooed on the back of his neck. He is the culmination of decades of research ­ and forty-six earlier Agent clones -- endowing him with unprecedented strength, speed, stamina and intelligence. His latest target is a mega-corporation that plans to unlock the secret of Agent 47's past to create an army of killers whose powers surpass even his own. Teaming up with a young woman who may hold the secret to overcoming their powerful and clandestine enemies, 47 confronts stunning revelations about his own origins and squares off in an epic battle with his deadliest foe.

A couple moves into an old house inhabited by the man's half-brother, who escaped hellish torture from the Cenobites but returned shorn of his skin. The Cenobites, are triggered by a Rubik's Cube-like puzzle device that unlocks the gates of hell and would like another meeting with the man.