A young girl named Emily discovers a small red puppy who magically becomes a gigantic dog. The significant growth of the dog attracts the attention and interest of a genetics company. Emily and her Uncle Casey (Whitehall) have to fight the forces of greed as they go on the run across New York City. Along the way, Clifford affects the lives of everyone around him and teaches Emily and her uncle the true meaning of acceptance and unconditional love.
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